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Toxic Legacy: How the Weedkiller Glyphosate is Destroying our Health and the Environment

By Stephanie Seneff

Named a “Best Book of the Year” by Kirkus Reviews

Toxic Legacy explores how toxic Glyphosate is to the environment.  While it has been claimed to be safe, it actually is not.  Find out more in this book.

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Toxic Legacy argues that glyphosate, the active ingredient in the herbicide Roundup, is a major contributor to the skyrocketing rates of chronic diseases, such as cancer, autism, and infertility. Seneff, a senior research scientist at MIT, presents compelling evidence from peer-reviewed scientific studies to support her claims.

Seneff begins by discussing the mechanism of action of glyphosate. Glyphosate is an inhibitor of the enzyme EPSPS, which is essential for the production of the amino acid phenylalanine. Phenylalanine is a building block for many proteins, including those involved in cell signaling, detoxification, and immunity.

Seneff argues that glyphosate’s inhibition of EPSPS can have a wide range of negative health effects. For example, it can damage the gut microbiome, leading to dysbiosis and inflammation. It can also interfere with the production of proteins that are important for detoxification, making the body more vulnerable to toxins. Additionally, glyphosate can damage DNA and RNA, which can lead to cancer and other health problems.

Seneff also discusses the environmental impact of glyphosate. She argues that glyphosate use is contributing to the decline of pollinators, such as bees and butterflies. Glyphosate can also contaminate water supplies and harm aquatic organisms.

Toxic Legacy concludes by calling for a ban on glyphosate and a transition to more sustainable agricultural practices. Seneff argues that we need to move away from the use of synthetic herbicides and pesticides and towards more natural methods of pest control.

“Toxic Legacy” is a well-researched and informative book that provides a comprehensive overview of the potential health and environmental risks of glyphosate. It is an essential read for anyone who wants to learn more about this important issue.

Here are some additional resources that you may find helpful:

  • The Silent Spring Institute: An organization that works to protect public health and the environment from the harmful effects of pesticides.
  • The Environmental Working Group: An organization that provides information on environmental health issues.
  • The Natural Resources Defense Council: An organization that works to protect the environment.


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